Diovan 80mg Tablet 14pcs

✔️ Uses of Diovan 80mg Tablet

• Hypertension
• Myocardial Infarction
• Heart Failure

✔️ How does Diovan 80mg Tablet work?

Diovan 80mg Tablet makes blood vessels relax, reduces cardiac output, and thus lowers blood pressure by blocking the effects of Angiotensin II (a substance produced in your body that causes the narrowing of blood vessels).

✔️ Side Effects of Diovan 80mg Tablet

• Headache
• Dizziness
• Nausea
• Stomach pain
• Diarrhea
• Indigestion
• Tiredness
• Body pain
• Cough
• Runny or stuffy nose
• Sore throat
• Swelling
• Low blood pressure

✔️ Quick Suggestions:

• Diovan 80 mg Tablet is used to treat high blood pressure. It can be taken with or without food.
• Do not break, chew, or crush the tablet. Swallow as a whole with a sufficient amount of water.
• Try taking this medicine at the same time every day for ease of remembering.
• It is important to make lifestyle changes like exercising regularly and eating a low-sodium diet for better control of blood pressure.
• This medicine may cause an increase in potassium levels in the body. Hence avoid potassium-rich foods while taking Diovan 80 mg Tablet.
• Avoid the discontinuation of Diovan 80 mg Tablet without consulting your doctor even if you feel better after a few doses, as it is a long-term treatment.
• Keep Diovan 80 mg Tablet away from children and pets.
• Diovan 80 mg Tablet can cause dizziness, so get up slowly from a sitting position to avoid feeling dizzy.
• Check the expiry date before taking it.

✔️ Hypertension Overview:

Hypertension, also known as high blood pressure, is a medical condition characterized by elevated force of blood against artery walls. This condition can lead to serious health problems, including heart disease, stroke, and kidney failure.

Types of Hypertension:

Primary Hypertension:

• Develops over the years.
• No specific cause was identified.

Secondary Hypertension:

• Can result from various underlying causes.
• Examples include obstructive sleep patterns, kidney problems, adrenal gland tumors, thyroid problems, congenital defects, certain medications, and substance abuse.

Causes of Hypertension:

• Blood plasma volume
• Hormone activity
• Stress
• Lack of physical activity
• Chronic kidney disease
• Diabetes
• Obesity
• Sleep apnea
• Pregnancy
• Cushing syndrome

Symptoms of Hypertension:

• Severe headache
• Fatigue or confusion
• Palpitation
• Chest pain
• Blood in the urine
• Blurred vision
• Difficulty breathing

Normal Blood Pressure Levels:

• Systolic: Below 120 mm Hg
• Diastolic: Below 80 mm Hg

Stages of Hypertension:

Normal:

• Systolic: Below 120 mm Hg
• Diastolic: Below 80 mm Hg

Pre-hypertension:

• Systolic: 120-139 mm Hg
• Diastolic: 80-89 mm Hg

Stage-1 Hypertension:

• Systolic: 140-159 mm Hg
• Diastolic: 90-99 mm Hg

Stage-2 Hypertension:

• Systolic: 160 mm Hg and above
• Diastolic: 100 mm Hg and above

Diagnosis:

• Routine checkup
• Blood pressure measurement
• Age group consideration (18-39, 40+)

Treatment:

Age 55 and Above:

• Initial: Calcium channel blocker or thiazide-type diuretic
• Second Drug: ACE inhibitor or angiotensin receptor

Below 55 Years:

• Initial: ACE inhibitor or angiotensin receptor
• Second Drug (if needed): Calcium channel blocker or thiazide-type diuretic

Three-Drug Therapy:

• A combination of ACE inhibitor or angiotensin receptor blocker, calcium channel blocker, and thiazide-type diuretic may be advised.

✔️ Pharmacology

• Valsartan is a specific angiotensin II antagonist with oral activity.
• It acts on the AT1 subtype of angiotensin II receptors.
• Angiotensin II is a substance that, when it binds to its receptors, causes blood vessels to narrow (vasoconstriction).
• This narrowing of blood vessels leads to an increase in blood pressure (hypertension).
• Valsartan blocks the angiotensin II receptors, specifically targeting the AT1 subtype.
• By blocking the effects of angiotensin II, Valsartan can dilate blood vessels.
• Valsartan's action on blood vessels helps lower blood pressure.
• Importantly, it achieves this without affecting the pulse rate.
• The affinity of Valsartan for the AT1 receptor is significantly higher than that for the AT2 receptor, approximately 20,000 times.
• Valsartan does not bind to or block other hormone receptors or ion channels that are known to be important for cardiovascular regulation.

✔️ Dosage & Administration of Diovan 80mg Tablet

Hypertension:

• Usual Dose: 80 to 160 mg once daily.
• Maximum Dose: 320 mg daily.
• Maximum blood pressure reduction occurs within 4 weeks.

Heart Failure:

• Usual Dose: 40 mg twice daily.
• Dose Adjustment: May be increased to 80-160 mg twice daily.

Post-Myocardial Infarction:

• Initial Dose: 20 mg twice daily.
• Target Dose: 160 mg daily if tolerated without side effects.

Administer Valsartan on an empty stomach. Administration with food decreases Valsartan absorption by about 40%.

✔️ Interaction

Before taking Diovan 80mg Tablet, inform your doctor if you are taking any of the following medications:

• Angiotensin II Receptor Blockers (ARBs): Telmisartan, Losartan, Valsartan
• Aliskiren or Angiotensin Converting Enzyme Inhibitors (ACE Inhibitors): Enalapril, Lisinopril, Ramipril
• Diuretics: Furosemide, Hydrochlorothiazide (used to treat edema or high blood pressure)
• Beta Blockers: Atenolol, Propranolol, Carvedilol (used to manage abnormal heart rhythms)
• Potassium Supplements and Salt Substitutes: These raise potassium levels in the body.
• Heparin: Used to prevent blood clotting.
• Mineralocorticoid Receptor Antagonists: Spironolactone, Eplerenone (used to treat high blood pressure and heart failure)
• Non-steroidal anti-inflammatory Drugs (NSAIDs): Aspirin, Ibuprofen
• Rifamycin: Used against bacterial infections.
• Ciclosporin: Used to protect against transplant rejection.
• Ritonavir: Used to treat HIV/AIDS infection.
• Lithium-Containing Medications: Used to treat some types of depression.

✔️ Contraindications

• Hypersensitivity
• Severe Liver Impairment
• Primary Biliary Cirrhosis
• Kidney Impairment
• Diabetes Mellitus

✔️ Pregnancy & Lactation

Pregnancy: Valsartan should not be used during pregnancy because it can cause fetal injury or even death in the second and third trimesters. When pregnancy is detected, valsartan treatment should be stopped as soon as possible. 
Lactation: Whether valsartan is excreted in human milk is unclear. Due to the possibility of adverse reactions in breastfeeding infants, the importance of the drug to the mother should be considered and the decision to stop breastfeeding or medication should be stopped.

✔️ Precautions & Warnings

✔️ Storage Conditions

Store this medicine at room temperature.